What is Semaglutide? Semaglutide is a GLP-1 receptor agonist studied extensively for its effects on metabolic regulation, appetite signaling and glucose metabolism. Research Areas GLP-1 receptor activity Appetite signaling Caloric-intake regulation Glucose metabolism Insulin signaling Body-composition research Why is it being researched? GLP-1 signaling plays an important role in regulating appetite and food intake as well as glucose-dependent insulin secretion. Semaglutide has therefore become an important compound in metabolic research. PRIMAL RESEARCH NOTE: Semaglutide is an approved pharmaceutical ingredient in specific prescription products, but an independently supplied research vial should not be represented as an approved medication.