What is Retatrutide? Retatrutide is an investigational peptide that activates three hormone receptors: GLP-1, GIP and glucagon. Because it acts across three metabolic pathways, it has become an extensively studied compound in metabolic and body-composition research. Research Areas GLP-1, GIP and glucagon receptor activity Appetite and satiety signaling Glucose metabolism Energy expenditure Lipid and fat metabolism Body-composition research Why is it being researched? Retatrutide is particularly interesting because it combines three distinct metabolic signaling pathways in a single molecule. Current clinical research is examining its potential effects across obesity, type 2 diabetes and other metabolic conditions. PRIMAL RESEARCH NOTE: Retatrutide remains investigational and is not currently FDA-approved.